Purpose Colorectal cancer (CRC) remains a significant global health burden, necessitating innovative approaches for prevention and treatment.This study proposes a multiepitope vaccine targeting carcinoembryonic antigen (CEA) and insulin-like growth factor-1 receptor (IGF-1R), two prominent biomarkers associated with CRC progression.Methods Sequence
This paper proposes novel randomized gossip-consensus-based sync (RGCS) algorithms to realize efficient time calibration in dynamic wireless sensor networks (WSNs).First, the unreliable links are described by stochastic connections, reflecting the characteristic of changing connectivity gleaned from dynamic WSNs.Secondly, based on the mutual drift
T-cell responses are crucial for the outcome of any infection.The type of effector T-cell reaction is determined by a complex interaction of antigen-presenting cells with naive T cells and involves genetic and environmental factors, including the type of antigen, cytokines, chemokines, co-stimulatory molecules, and signalling cascades.The us polo a
Minimal residual disease (MRD) refers to a very deus gorras small number of residual tumor cells in the body during or after treatment, representing the persistence of the tumor and the possibility of clinical progress.Circulating tumor DNA (ctDNA) is a DNA fragment actively secreted by tumor cells or released into the circulatory system during the